Palazzo Fiuggi.
The most technology-forward new entrant in European longevity medicine. Opened 2021 in a restored twentieth-century palace in Italy's historic thermal spa town. PEMF, cryotherapy, vagus nerve activation, and the Fiuggi thermal water — the biohacking end of the clinical-resort category.
Programmes offered.
Palazzo Fiuggi structures its offer around named seven-night medical programmes, each with a specific health focus. All programmes are all-inclusive (programme fee, accommodation, full board). The Classic Medical Retreat is the entry-level all-rounder.
Classic Medical Retreat
The foundation programme covering all core Palazzo Fiuggi therapies: comprehensive medical assessment, biomarker panel, PEMF therapy sessions, cryotherapy, IV drip protocol, movement science sessions, and full use of the thermal water spa. The broadest programme — suited to first-time visitors who want to experience the full range before specialising.
Detox & Metabolic Balance
A gut and metabolic reset focused on eliminating toxins, resetting blood sugar regulation, and optimising liver function. Combines the thermal Fiuggi water protocol (known historically for lithium content and kidney/digestive effects), IV antioxidant therapy, therapeutic fasting-supported meals, colonic hydrotherapy, and a personalised metabolic panel review.
Immune Boost & Prevention
Immune function testing (NK cell activity, T-cell profiling, inflammatory cytokine panel), high-dose vitamin C and zinc IVs, ozone therapy, PEMF sessions focused on lymphatic stimulation, and a nutrition programme designed around anti-inflammatory and immune-supporting foods. Developed post-2021 for guests with chronic immune dysfunction or those in oncology recovery.
Optimal Weight
Metabolic profiling, body composition analysis, resting metabolic rate testing, and personalised caloric prescription. Daily movement science sessions (functional movement assessment, personalised exercise prescription, hydrotherapy). Combined with the broader biomarker panel and a post-stay dietary protocol. Not primarily a weight-loss retreat — focused on metabolic health optimisation with weight management as a downstream outcome.
Longevity & Anti-Ageing
The most comprehensive and most expensive single programme at Palazzo Fiuggi. Full advanced biomarker panel (epigenetic age, telomere length, metabolomics, microbiome), maximum treatment allocation including daily PEMF, daily vagus nerve stimulation, cryotherapy, NAD⁺ infusion, and a dedicated longevity physician consultation producing a five-year health optimisation plan.
Cardio Health
Advanced cardiovascular diagnostics: carotid intima-media thickness scan, coronary calcium scoring (CT), full lipid sub-fractionation (ApoB, ApoA-1, LDL particle size), hs-CRP, homocysteine, lipoprotein(a), exercise ECG. Interventions include PEMF for vascular health, targeted IV protocols, and a cardiovascular nutrition plan. Designed for guests with elevated CV risk or a family history of cardiac events.
Cognitive Performance
Cognitive assessment battery, neurofeedback sessions, transcranial photobiomodulation (red light therapy applied to the skull for neurological effect), NAD⁺ infusions, sleep architecture analysis, and a nutrition protocol focused on brain-supporting compounds (omega-3, lion's mane, phosphatidylserine). Draws from emerging research in neuroplasticity and brain ageing.
Classic Medical Retreat (7 nights) — full breakdown.
The entry programme and the broadest all-rounder. Seven nights all-inclusive. ~£8,300 for a Charme Room single occupancy — approximately 1.7× the Long Week all-in.
Day one — medical assessment.
- Physician consultation; full diagnostic blood draw (metabolic, hormonal, inflammatory, cardiovascular, nutritional)
- Body composition analysis
- Resting ECG
- Fitness assessment — strength, flexibility, balance, cardiovascular
- Treatment schedule personalised based on findings and stated goals
Signature technology treatments.
- PEMF (Pulsed Electromagnetic Field) — low-frequency electromagnetic pulses for cellular repair, inflammation, mitochondrial function. 30–60 min sessions, 2–3 across the week
- Vagus nerve stimulation (taVNS) — auricular clip delivering micro-currents to shift the autonomic nervous system into parasympathetic dominance
- Whole-body cryotherapy — chamber sessions at −110°C for 2–3 minutes, scheduled morning or post-movement
- Daily IV therapy — formulation tailored to blood results (vitamin C, B-complex, magnesium, trace elements). 3–4 sessions across the week
Movement science.
- Functional movement assessment on arrival
- Daily personalised sessions — mobility, strength, cardiovascular
- Aquatic therapy in the historic thermal pool
- Sessions integrated into the programme schedule, not optional
Vagal activators (supporting).
- Breathing protocols (resonant frequency, box breathing)
- Cold exposure
- Singing bowl sound therapy
Fiuggi thermal water protocol.
- Prescribed daily intake of the famous low-mineral Fiuggi spring water
- Medical supervision on quantities
- Used in hydrotherapy treatments alongside drinking protocol
Summary & comparison to The Long Week. Palazzo Fiuggi is the most technology-dense competitor and positions itself at the biohacking end of the clinical category. The Classic Medical Retreat at £8,300 all-in is 1.7× our Long Week at £4,995. The clinical registers differ: Fiuggi leads with devices (PEMF, cryotherapy, taVNS); The Long Hotel leads with hands-on clinical work (Ayurvedic physician contact, Panchakarma-derived treatments, Eight Sleep sleep diagnostics). A guest choosing between us is essentially choosing between a technology-forward or a human-contact-forward experience at a significant price differential.
Inspiration for The Long Hotel. Three Fiuggi elements worth borrowing. First, the vagus nerve focus as a programme thread — Fiuggi explicitly frames the week as "moving the guest from sympathetic to parasympathetic dominance" and uses HRV before/after as the proof. We could adopt this same explicit framing for The Long Week using HRV from the Eight Sleep platform plus our breathwork sessions and Ayurvedic Shirodhara as the parasympathetic toolkit. Second, the place-bound therapeutic resource as a hero element — they have built the entire programme around the Fiuggi spring water, a genuine local asset. Our equivalent is the Jersey coastline and seawater — we should formalise a sea-bathing or thalassotherapy element as a named, scheduled, marketed pillar rather than leaving it as ambient context. Third, the movement science integrated into the daily schedule rather than being optional — Fiuggi makes movement compulsory and personalised. We should similarly assign each guest a daily movement slot rather than letting the schedule drift toward "yoga is available."